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GHRP-6

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Clinical — 10 studies

GHRP-6 is a growth hormone–releasing peptide studied for GH stimulation and appetite-related ghrelin signaling.

Being studied for

GH secretion researchGhrelin receptor signaling

Published Research

Evidence profile

Human Phase 1 evidence

10 cited publications · 6 primary trials

Findings below belong to the studies that reported them. They describe the material and conditions those authors used, not this product, and not an outcome to expect.

Supporting evidence

ClinicalPrimary trial · Phase 1

Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers

Cabrales A et al. · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2013

The study reportedDose dependence analysis revealed a noticeable trend for AUC to increase proportionally with administered dose. Atypical GHRP-6 concentration spikes were observed during the elimination phase in four out of the nine subjects studied.

PMID 23099431DOI 10.1016/j.ejps.2012.10.006
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ClinicalPrimary trial

Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment

Molica P et al. · Pituitary · 2010

The study reportedOur results suggest that the pathways of GH release after ghrelin/GHRP-6 and GHRH are similarly affected by thyroid hormone excess and hypothalamic mechanisms of ACTH release modulated by ghrelin/GHSs may be activated in this situation.

PMID 20602173DOI 10.1007/s11102-010-0238-3
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ClinicalPrimary trial

Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism

Pimentel-Filho FR et al. · Clinical endocrinology · 1997

The study reportedWe have shown that patients with primary hypothyroidism have higher GH responses to GHRP-6 than to GHRH, which are markedly blunted. When GHRP-6 was associated with GHRH, a significant increase in the GH response was observed in these patients, which could suggest a role for somatostatin in this process.

PMID 9156038DOI 10.1046/j.1365-2265.1997.1270942.x
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ClinicalPrimary trial

Different effects of growth hormone releasing peptide (GHRP-6) and GH-releasing hormone on GH release in endogenous and exogenous hypercortisolism

Borges MH et al. · Clinical endocrinology · 1997

The study reportedOur results suggest that hypercortisolism had a different effect on the GH-releasing mechanisms stimulated by GHRH and GHRP-6. Moreover, in endogenous hypercortisolism both GHRH and GHRP-6 pathways are affected, while in the exogenous group GHRP-6 releasing mechanisms are apparently preserved.

PMID 9274702DOI 10.1046/j.1365-2265.1997.1981008.x
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ClinicalPrimary trial

Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood

Micic D et al. · Clinical endocrinology · 1995

The study reportedThese data show that GH responses to GHRP-6 are much greater than to GHRH in late adulthood. The marked increase of plasma GH levels observed after administration of GHRP-6 alone or in combination with GHRH indicates that impaired GH secretion in late adulthood is a functional and potentially reversible state.

PMID 7734029DOI 10.1111/j.1365-2265.1995.tb01861.x
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ClinicalPrimary trial

Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man

Frieboes RM et al. · Neuroendocrinology · 1995

The study reportedBoth GHRP and GHRH promote sleep. However, GHRP enhances stage 2 sleep and does not affect SWS.

PMID 7617137DOI 10.1159/000126883
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Additional indexed literature (4)

Published studies summarised here concern the specific investigational or pharmaceutical materials and study conditions described by their authors. Their findings are not performance claims for Lucid Peptides material. Citations verified against PubMed on 2026-08-09.

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