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Research Summary

HCG (Human Chorionic Gonadotropin)

Research Hub
Clinical — 10 studies

HCG is a glycoprotein hormone studied for its role in luteinizing hormone receptor activation and endocrine signaling.

Being studied for

Endocrine signaling pathwaysGonadal hormone research

Published Research

Evidence profile

Controlled human evidence

10 cited publications · 2 primary trials

Findings below belong to the studies that reported them. They describe the material and conditions those authors used, not this product, and not an outcome to expect.

Supporting evidence

ClinicalPrimary trial

Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study

Habous M et al. · BJU international · 2018

The study reportedAll three treatments were equally effective in restoring testosterone levels. Single-agent CC is simple, cheap and may be used as treatment for hypogonadism when maintenance of fertility is desired. This approach seems to be as effective as either hCG alone or a combination of hCG and CC.

PMID 29772111DOI 10.1111/bju.14401
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ClinicalPrimary trial

Late-onset hypogonadism: the advantages of treatment with human chorionic gonadotropin rather than testosterone

La Vignera S et al. · The aging male : the official journal of the International Society for the Study of the Aging Male · 2016

The study reportedFinally, all the groups treated with T showed a significant reduction (p < 0. 05) of sperm density and of percentage of spermatozoa with progressive motility compared with HCG group.

PMID 26488941DOI 10.3109/13685538.2015.1092021
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ReviewMeta-analysis

Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis

Alexander EC et al. · European journal of endocrinology · 2024

The study reportedThis systematic review provides convincing evidence of the efficacy of gonadotropins for pubertal induction. However, there remains substantial heterogeneity in treatment choice, dose, duration, and outcomes assessed. Formal guidelines and randomized studies are needed.

PMID 38128110DOI 10.1093/ejendo/lvad166
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ReviewMeta-analysis · Phase 3

A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle-stimulating hormone and human chorionic gonadotropin

Warne DW et al. · Fertility and sterility · 2009

The study reportedR-hFSH (combined with hCG) is effective for the restoration of fertility in the majority of men with HH.

PMID 18930225DOI 10.1016/j.fertnstert.2008.07.1720
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Additional indexed literature (6)

Published studies summarised here concern the specific investigational or pharmaceutical materials and study conditions described by their authors. Their findings are not performance claims for Lucid Peptides material. Citations verified against PubMed on 2026-08-09.

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