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Research Summary

LEMON BOTTLE (Riboflavin, Bromelain, Lecithin)

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Clinical — 10 studies

LEMON BOTTLE is a formulation containing riboflavin, bromelain, and lecithin, explored in cosmetic and adipose tissue research contexts.

Being studied for

Localized adipose tissue researchCosmetic formulation studies

Published Research

Evidence profile

Component evidence only — this formulation has not itself been studied

10 cited publications · 2 primary trials

LEMON BOTTLE (Riboflavin, Bromelain, Lecithin) has not itself been studied in the published literature. The studies below examined its individual components and are labelled accordingly: Lecithin / phosphatidylcholine, Riboflavin, Bromelain. Findings belong to the component named on each card, not to this formulation.

Supporting evidence

ClinicalPrimary trial
Evidence for Lecithin / phosphatidylcholine

Tissue-toxic effects of phosphatidylcholine/deoxycholate after subcutaneous injection for fat dissolution in rats and a human volunteer

Schuller-Petrovic S et al. · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2008

The study reportedInjection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety of PC/DC for nonsurgical treatment of subcutaneous fat deposits uncertain.

PMID 18370980DOI 10.1111/j.1524-4725.2008.34128.x
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ClinicalPrimary trial
Evidence for Lecithin / phosphatidylcholine

Fat tissue after lipolysis of lipomas: a histopathological and immunohistochemical study

Bechara FG et al. · Journal of cutaneous pathology · 2007

The study reportedLipolysis with PDC results in a distinct inflammatory reaction of affected fat tissue, similar to factitial panniculitis. Early destruction of fat cells may suggest the involvement of detergent or osmotic mechanisms in the process.

PMID 17576334DOI 10.1111/j.1600-0560.2006.00651.x
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ReviewSystematic review
Evidence for Riboflavin

Effects of deficiency or supplementation of riboflavin on energy metabolism: a systematic review with preclinical studies

da Silva-Araújo ER et al. · Nutrition reviews · 2025

The study reportedThis review concludes that riboflavin regulates energy metabolism by activating primary metabolic pathways and is involved in energy balance homeostasis.

PMID 38719205DOI 10.1093/nutrit/nuae041
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ReviewMeta-analysis
Evidence for Bromelain

Bromelain-Based Enzymatic Debridement Versus Standard of Care in Deep Burn Injuries: A Systematic Review and Meta-Analysis

De Freitas LR et al. · Journal of burn care & research : official publication of the American Burn Association · 2025

The study reportedBromelain-based enzymatic debridement may accelerate eschar removal and reduce the need for surgical excision and autografts, without adversely affecting wound closure time or long-term scar quality.

PMID 39259807DOI 10.1093/jbcr/irae172
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ReviewMeta-analysis
Evidence for Bromelain

Efficacy and safety of bromelain: A systematic review and meta-analysis

Leelakanok N et al. · Nutrition and health · 2023

The study reportedConclusions: Moderate-quality studies demonstrated the potential of oral bromelain in pain control and topical bromelain in wound care. Major health risks were not reported during the treatment with bromelain.

PMID 37157782DOI 10.1177/02601060231173732
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ReviewMeta-analysis
Evidence for Bromelain

Oral Bromelain for the Control of Facial Swelling, Trismus, and Pain After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis

Liu S et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2019

The study reportedBromelain conferred moderate relief of postoperative discomfort after third molar surgery.

PMID 30986376DOI 10.1016/j.joms.2019.02.044
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ReviewMeta-analysis
Evidence for Bromelain

Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta-analysis

de Souza GM et al. · Phytotherapy research : PTR · 2019

The study reportedThe results suggest that the bromelain appears to be effective in the control of pain, edema, and trismus after lower third molar surgeries; however, further high-quality studies are needed to confirm this finding.

PMID 30484910DOI 10.1002/ptr.6244
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Additional indexed literature (3)

Published studies summarised here concern the specific investigational or pharmaceutical materials and study conditions described by their authors. Their findings are not performance claims for Lucid Peptides material. Citations verified against PubMed on 2026-08-09.

LEMON BOTTLE is presented in the context of cosmetic and formulation research and is not a medicinal product.

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